The project of mapping Springfield will probably be of interest to information architecture, taxonomy and information design geeks due to the fact that there is list of items to be mapped based on anecdotal evidence (like watching the show). This is not unlike architecting a web app after a discovery/JAD session.
It won't be easy. Across the street from The Simpsons's house you will see a highway, an open field or Gerald Ford's house based on the given episode. This is also a problem in web app design/development due to constantly changing requirements and business needs that need to be accommodated in some way. This is on top of the information design issues they face since there is such a massive amount of stuff to be physically mapped.