Being a Mac user, and being an Interface Geek as well, Adobe applications are my power tools and to extend that metaphor, Mac OS X is my current source of energy. Unfortunately, the core tool, Photoshop, is still not OSX native. But it looks like that will be changing soon.
MacPlus, a French language OSX website has screen shots of several Adobe apps that are coming to OSX in native code. RAILhead Design has also been posting information about the pending release of Photoshop 7 that is greatly encouraging. I would link directly to a relevant URL, but he's using frames and you will need the navigation frame to get around.